Department of Medicine

Case Western Reserve University School of Medicine & UH Case Medical Center

Neal Meropol MD discusses FDA decision to remove Avastin for breast cancer treatment

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Roland Moskowitz MD discusses rheumatoid arthritis with ABC News

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Neal Meropol MD discusses chemo drug Taxol shortage and how it could put cancer patients at risk

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Reena Mehra MD discusses the danger of sleep apnea

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Best Doctors in America

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Congratulations to our hardworking physicians who were awarded the title of “Best Doctors in America” in 2011. The Department of Medicine is proud to have over 60 our our physicians recognized in this award.

Division of Cardiovascular Medicine

Dr. Mauricio S. Arruda
Dr. Marco A. Costa
Dr. Michael J. Cunningham
Dr. Barry A. Effron
Dr. James Fang
Dr. Michel George Farah
Dr. Robert Goldstein
Dr. Lloyd Greene
Dr. A. Arthur Halle III
Dr. Brian Hoit
Dr. Richard A. Josephson
Dr. Joseph I. Krall
Dr. Judith Mackall
Dr. Sri Krishna Madan Mohan
Dr. Carl E. Orringer
Dr. Aaron Proweller
Dr. Daniel I. Simon
Dr. Bruce S. Stambler
Dr. Sergey Vitebskiy (EP Fellow)
Dr. Albert L. Waldo
Dr. Thomas S. Wilson

Division of Endocrinology

Dr. Baha Mahmoud Arafah
Dr. Adrian M. Schnall

Division of Gastroenterology & Liver Disease

Dr. Robert B. Cameron
Dr. Amitabh Chak
Dr. Fabio Cominelli
Dr. Gregory S. Cooper
Dr. Ashley L. Faulx
Dr. Kevin Geraci
Dr. Gerard Isenberg
Dr. Jeffry A. Katz
Dr. Michael K. Koehler
Dr. Eric J. Shapiro
Dr. Sapna V. Thomas
Dr. Richard C.K. Wong

Division of Infectious Disease

Dr. Keith B. Armitage
Dr. Barbara M. Gripshover
Dr. Michael M. Lederman
Dr. Robert A. Salata

Division of Oncology and Hematology

Dr. Matthew Morrissey Cooney
Dr. Brenda W. Cooper
Dr. Afshin Dowlati
Dr. Stanton L. Gerson
Dr. Joseph Gibbons
Dr. Smitha Subramanyan Krishnamurthi
Dr. Hillard Michael Lazarus
Dr. Nathan Levitan
Dr. Neal J. Meropol
Dr. Alvin H. Schmaier
Dr. Paula Silverman

Division of Nephrology

Dr. Peter DeOreo
Dr. Donald E. Hricik
Dr. Michael C. Smith
Dr. Jay B. Wish

Division of Pulmonary, Critical Care & Sleep Medicine

Dr. Rana B. Hejal
Dr. Reena Mehra
Dr. Hugo Montenegro
Dr. Robert John Schilz
Dr. Kingman P. Strohl

Sugary Drinks Might Raise Hypertension Risk

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BusinessWeek

Drinking sugar-sweetened sodas and fruit drinks appears to be associated with a greater risk for high blood pressure among adults, a new study suggests.

Dr. Sahil Parikh, Professor in the Division of Cardiovascular Medicine, and cardiologist at the Harrington Heart & Vascular Institute at University Hospitals Case Medical Center in Cleveland, said the findings “fall along the lines of the kind of common sense your mother would offer.”

“We have long known that sugary drinks are bad for you, because they are a lot of empty calories,” he said. “But what makes this study important is that it suggests that beyond just making you fatter these drinks also prompt hypertension, which can increase the incidence of heart attack and stroke.”

“Now we will need to have future studies to understand how this works,” Parikh added, “because even though this data shows a pretty clear association between sugary drinks and high blood pressure, it doesn’t definitively suggest a mechanistic link.”

“Having said that, as a cardiologist my concern is how do we minimize our risk factors for cardiovascular events,” he continued. “And we know the way to do that is to avoid tobacco use and avoid obesity. So to the extent that one can control calorie intake, there really isn’t a downside to eliminating sugar drinks. They’re empty calories of limited value. So why not do that?”

In response to the latest findings, the American Beverage Association issued a statement Monday saying that while high blood pressure is “a serious health concern,” the current study “does not and cannot establish that drinking sugar-sweetened beverages in any way causes hypertension.”

Read the full story :: BusinessWeek

The Unrealistic Optimism of Cancer Patients

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The New York Times

As a medical student and later during my residency, I trained for some time in a medical center known for its research and clinical trials. Every week, patients with rare diseases and cancers that had not responded to standard therapy arrived from all over the country, eager to try something new, even if the efficacy of the treatments had not yet been proven.

But placed in the context of early-phase clinical cancer trials, unrealistic optimism results in a perfect ethical storm. “You have oncology, a field of medicine that is strongly evidence-based and research-intensive, and you have a population of patients who are experiencing an immediate threat to their lives,” said Dr. Neal J. Meropol, a researcher who has done extensive work on the ethics of early-phase cancer trials and chief of the division of hematology and oncology at University Hospitals Case Medical Center and Case Western Reserve University in Cleveland.

“Patients almost invariably take part in early-phase clinical trials because they believe they will personally benefit.”

Read the full story :: New York Times

Reducing The Recurrence Of Aggressive Breast Cancer Is The Object Of Novel Clinical Trial

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In a first-of-its-kind clinical trial, physician-scientists are exploring a new method to potentially prevent recurrence of an early stage, aggressive type of breast cancer.

The pilot study, conducted by Joe Baar, MD, Professor, Division of Hematology Oncology, Director of Breast Cancer Research at UH Case Medical Center’s Seidman Cancer Center, is recruiting patients with HER-2 neu+ breast cancer. “This study has the potential to change the standard of care for women with this type of breast cancer, which tends to spread very quickly,” says Dr. Baar, who is also Associate Professor of Medicine at Case Western Reserve University School of Medicine.

Read the full article :: Medical News Today

FDA Grants 510(k) Clearance To Life Technologies Stem Cell Growth Medium

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Life Technologies Corporation (Nasdaq: LIFE) announced it has received FDA 510(k) clearance for StemPro® MSC SFM a first for this next-generation stem cell culture medium that is now cleared as a medical device and satisfies a crucial requirement for researchers involved in clinical trials in the United States…”

An FDA-cleared, serum-free medium certainly provides a positive step toward moving away from mostly animal-based products for growing mesenchymal stem cells,” said Stanton L. Gerson, MD, Professor, Division of Hematology Oncology in the Department of Medicine, Director, University Hospitals Seidman Cancer Center and the National Center for Regenerative Medicine, at Case Western Reserve University, a pioneer in the use of adult stem cells to treat cancer and heart disease who is also part of a team conducting early phase clinical trials with MSCs to treat graft-versus-host disease and multiple sclerosis. “Growth media that is better defined can facilitate regulatory requirements. Ultimately, clinical trials will determine whether it benefits patients.”

Gerald Isenberg, MD, discusses the 10 Worst Foods for Your Stomach with AOL Health

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AOL Health
If you think you’re the only one who suffers from belching, stomach bloating and abdominal discomfort on a regular basis, think again: The most current statistics from the Center for Disease Control and Prevention state that the average number of annual visits to physician offices and hospitals regarding digestive system conditions total 42.2 million. And according to the American College of Gastroenterology, more than 95 million Americans suffer from poor digestion.

The common culprits for digestive issues are cooked food, since heat destroys the natural enzymes found in raw foods that aid in digestion, and aging, due to a decline in enzyme production of about 13 percent with each passing decade, said Dr. Steven Lamm, a board-certified internist and faculty member at the NYU Medical Center.

While those who suffer from irritable bowel syndrome, heartburn, acid reflux (also known as gastroesophageal reflux disease) or an ulcer will have various reactions to different foods and drinks, experts agree the following 10 items are likely to irritate one of more of these tummy-related conditions.

Stomach-sensitive food: mint
Why it can affect you: While peppermint has numerous benefits, including aiding in digestive issues, it can also have the reverse effect and increase heartburn symptoms, Dr. Gerald Ashton Isenberg, who works in the gastroenterology department at UH Case Medical Center in Cleveland, Ohio, told AOL Health. “Mint increases the chance of acid reflux because it relaxes the lower esophageal sphincter, a muscle that is located at the end of the esophagus, allowing acid from the stomach to back up into the food pipe,” he explained. Keep in mind this holds true for anything that contains mint, such as peppermint tea and even peppermint gum and breath mints.

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