Message from the Division Chief, Dan Simon, MD


The Division of Cardiovascular Medicine is the driving force of the University Hospitals Harrington Heart & Vascular Institute and Case Cardiovascular Center of Case Western Reserve University School of Medicine in Cleveland, Ohio.

In July 2006, I joined University Hospitals as Chief of the Division of Cardiovascular Medicine with the goal to expand University Hospitals’ entire cardiovascular service line and to establish a Heart & Vascular Institute that would rise to the rank of a national center of excellence—not only in patient care, but also in regard to cardiovascular research and physician education.

The University Hospitals Harrington Heart & Vascular Institute, together with our affiliate Case Western Reserve University School of Medicine, is the focal point for clinical, research and educational activities related to heart and vascular disease. We are a nationally distinguished health care leader by innovating and pursuing new medical discoveries and providing the highest-quality patient care through personalized experiences.

Today, as President of University Hospitals Harrington Heart & Vascular Institute, I am proud of the milestones we have already achieved. We performed Ohio’s first cardiovascular stem cell trial, conducted the first clinically approved optical coherence tomography (OCT) coronary artery and CT-derived fractional flow reserve (FFR-CT) imaging procedures in the United States, serve as a Stereotaxis Center of Excellence for complex ablation, and are experts in leading-edge technologies, including transcatheter aortic valve replacement (TAVR), MitraClip, percutaneous left ventricular restoration therapy, and thoracic endovascular aortic repair (TEVAR).

The Harrington Heart & Vascular Institute’s 11 centers include more than 140 physicians, surgeons, anesthesiologists, radiologists and researchers in cardiovascular medicine, cardiac and vascular surgery, electrophysiology, cardiovascular imaging, minimally invasive interventions, advanced heart failure and transplantation, onco-cardiology, stem cell regeneration and preventive strategies. These activities are based at University Hospitals Cleveland Medical Center and extend to 14 community medical centers and eight ambulatory health centers. The Harrington Heart & Vascular Institute provides primary cardiovascular services to local communities and tertiary and quaternary cardiovascular care to Northeast Ohio.

Our faculty members are nationally and internationally recognized authorities in many cardiovascular conditions including atrial fibrillation, interventional cardiology and heart failure. University Hospitals has a unique reputation for personalized, yet sophisticated cardiovascular care with a multidisciplinary approach. All patients are offered the latest in device, ablative, and surgical therapies. Greater than 13,000 cardiac catheterization and 4,500 electrophysiology procedures are performed annually. Our clinical programs are also closely aligned with the Louis Stokes Cleveland VA Medical Center, which serves as a regional center for cardiovascular services within the VA health care system.

We believe that research—from clinical research to population research and basic science—is fundamental to all top-flight cardiovascular medicine divisions, and we encourage all faculty members and fellows to be engaged in some aspect of research and discovery to advance patient care. Under the leadership of Mukesh Jain, MD, the Case Cardiovascular Research Institute (CVRI) has soared. The CVRI occupies over 13,000 square feet of laboratory space in the Wolstein Research Building and is home to over 70 faculty members, post-doctoral fellows, students and technicians. The strengths of the CVRI include vascular biology, gene regulation, hypertrophy, arrhythmia and electrical remodeling, and new programs in cardiovascular development and stem cell biology. Within the Harrington Heart & Vascular Institute’s Center for Research & Innovation, we have leading-edge translational and clinical research activities with particular strengths in stem cell and regenerative medicine, cardiovascular imaging, electrophysiology and interventional cardiology drug and device trials. We have 87 active clinical trials following greater than 2,500 patients and have garnered over 26 R01 grants from the National Institutes of Health, 11 career development awards (K-level awards from NIH and SDG from the American Heart Association), a T32 training grant and numerous industrial and foundation awards. Total committed grant support from the NIH now exceeds $32 million. We are particularly proud of our global research activities in Uganda related to rheumatic heart disease and cardiovascular complications of HIV/AIDS.

Our strong educational programs are under the leadership of Brian Hoit, MD, who serves a Director of the Fellowship training program. Our Cardiovascular Fellowship program has successfully matched house officers from elite medical institutions, including University of California-San Francisco, University of Texas-Southwestern, University of Michigan, Northwestern University, Emory, Cleveland Clinic Foundation, and, of course, University Hospitals Cleveland Medical Center. Subspecialty fellowships include electrophysiology, interventional cardiology, heart failure, and cardiovascular imaging. Many of our trainees have gone onto successful academic and clinical practice careers.